Endocrine Abstracts

Hypothyroidism is associated with higher risk of cardiovascular disease and increase of blood lipids. Previous evidence indicates that high dosage of levothyroxine could be cardiotoxic. There are fewer data describing mortality in subjects after treatment and stabilization of thyroid diseases and there are no data related to subjects with treated hypothyroidism. Aim of this study was to investigate correlations between the cardiovascular risk and metabolic status [Resting Ener...

Infrared Thermography (IT) is a non-invasive method and complementary to other diagnostic techniques to identify inhomogeneity of the thermal emission of the skin. We used IT (InfRec R500, Nippon Avionics Co.; 640×480 pixel, spatial resolution 0,87 mrad, sensitivity 0.03°C at 30°C, accuracy ±1°C) to assess the variations of skin temperature of the neck region: higher mean temperature, greater thyroid function. Primary outcome of this study was to compa...

Deep Transcranical Magnetic Stimulation (dTMS) is a non-invasive modulation technique of cortical excitability that has shown to affect the mesolimbic and mesostriatal dopaminergic pathways. Consistent with these assets, dTMS is widely used as a therapeutic tool in neuro-psychiatric disorders associated with abnormal cortical excitability and dopaminergic activity, as addiction. Hence, considering the dysfuncional role of PFC and dopaminergic reward system in controlling appet...

Weight loss in individuals with Obesity (O) and Type 2 Diabetes (T2D), may improve glycaemic control and weight-related comorbidities, and in some cases, induce diabetes remission. However, body weight control is generally an unmet aim in this population. Thus, there is an increasing need to consider pharmacological approaches to assist weight loss in diabetes-obesity. Glucose-lowering agents as the sodium-glucose co-Transporter 2 inhibitors (SGLT2i) and GLP-1 Receptor Agonist...

Obesity is known to be associated with increased heat production. To maintain normothermia, heat retention in areas of the body with greater adiposity is counteracted by an augmented heat release from the extremities, as the fingernail-beds of hands. A possible cause of the altered thermoregulation in obesity is a dysfunction of the neuro-endocrine system. Repetitive deep Transcranial Magnetic Stimulation (dTMS) was proved to be an effective tool in inducing long lasting chang...